Improving the Adverse Childhood

ARTICLE
Improving the Adverse Childhood
Experiences Study Scale
David Finkelhor, PhD; Anne Shattuck, MA; Heather Turner, PhD; Sherry Hamby, PhD
Objective: To test and improve upon the list of adverse
childhood experiences from the Adverse Childhood Experiences (ACE) Study scale by examining the ability of a
broader range to correlate with mental health symptoms.
Design: Nationally representative sample of children and
adolescents.
Setting and Participants: Telephone interviews with
a nationally representative sample of 2030 youth aged
10 to 17 years who were asked about lifetime adversities
and current distress symptoms.
Main Outcome Measures: Lifetime adversities and
participants, but the association was significantly improved (from R2 =0.21 to R2 =0.34) by removing some of
the original ACE scale items and adding others in the domains of peer rejection, peer victimization, community
violence exposure, school performance, and socioeconomic status.
Conclusions: Our understanding of the most harmful
childhood adversities is still incomplete because of complex interrelationships among them, but we know enough
to proceed to interventional studies to determine whether
prevention and remediation can improve long-term
outcomes.
current distress symptoms.
Results: The adversities from the original ACE scale items
were associated with mental health symptoms among the
JAMA Pediatr. 2013;167(1):70-75.
Published online November 26, 2012.
doi:10.1001/jamapediatrics.2013.420
T
Author Affiliations: Crimes
Against Children Research
Center, University of New
Hampshire, Durham
(Drs Finkelhor and Turner and
Ms Shattuck); and Psychology
Department, Sewanee, the
University of the South,
Sewanee, Tennessee
(Dr Hamby).
HE A DVERSE C HILDHOOD
Experiences (ACE) Study1
has attracted considerable
scientific and policy attention in recent years, in part
because it suggests that potentially preventable childhood experiences, particularly physical and sexual abuse and neglect, may increase a person’s risk for
serious health problems and higher mortality rates much later in life.
The study has demonstrated relationships between adverse childhood experiences and many adult health risks.1-10
These results, which have been published widely in the health sciences, are
based on a survey and medical records
of more than 17 000 members of the
Kaiser Health Plan in San Diego, California.1,11
Nonetheless, research using the ACE
Study model has some important limitations, in part because of the retrospective
way in which data on childhood adversities have been gathered. The average age
of respondents when they supplied information about their childhood experiences was 55 to 57 years. As a result, it is
hard to be certain, particularly from such
JAMA PEDIATR/ VOL 167 (NO. 1), JAN 2013
70
a remote vantage, whether it is these particular childhood experiences or unmeasured covariates that are the most important predictors. In addition, the ACE
Study list of preventable childhood
adversities omits certain domains judged
by many developmental researchers to be
important in predicting long-term health
and well-being outcomes. Among the
predictors missing from the ACE Study
model are peer rejection, exposure to
violence outside the family, low socioeconomic status, and poor academic
performance.
For editorial comment
see page 95
For example, longitudinal studies show
that growing up in poverty increases lifelong risk for various negative life events
and negative health outcomes.12-14 Peer rejection and lack of friends are associated
with the development of many disorders.15-17 Poor school performance in childhood is associated with poor outcomes in
adulthood, such as unemployment.18 Witnessing community violence has been
WWW.JAMAPEDS.COM
©2013 American Medical Association. All rights reserved.
Downloaded From: http://jamanetwork.com/ by George Morris on 04/20/2016
Author Aff
Against Ch
Center, Uni
Hampshire
Finkelhor a
Shattuck);
Departmen
University
Sewanee, T
Hamby).
shown to be a mental health hazard for adults and children.19,20 These major childhood adversities are not currently measured by the ACE scale.
In addition, measuring childhood adversities during
childhood, rather than later, may offer other improvements to the ACE Study’s early life predictors of health
outcomes.21 It allows the possibility of obtaining a more
accurate and comprehensive assessment of childhood
events than one would be able to obtain after many years.
It also would allow a more sensitive untangling of the
relationship among various adversities in ways that better explain causal sequences.
Although an obvious disadvantage is the inability to assess the long-term effects of childhood adversity on the negative life events and health conditions posited in the ACE
Study model, examining more short-term effects in childhood is consistent with the logic of the model. Specifically,
the ACE Study model relies strongly on the idea that adverse childhood experiences create a burden of psychological stress that changes behavior, cognitions, emotions, and
physical functions in ways that promote subsequent health
problems and illness.22 Among the hypothesized pathways,
adverse childhood experiences lead to depression and posttraumaticstressdisorder,whichinturncanleadtosubstance
abuse, sleep disorders, inactivity, immunosuppression, inflammatory responses, and inconsistent health care use, possibly leading to other medical conditions later in life.23,24
Therefore, childhood behavioral and emotional symptoms
verylikelyrepresentacrucialmediatorlinkingadversechildhood experiences and the longer term health-related problems found in the ACE substudies.
Thus, in the present study, we tried to replicate the
ACE Study findings in a cohort of youth, using psychological distress as an outcome measure, and to explore
whether the adversities enumerated by the ACE Study
could be improved upon by considering a more comprehensive range of possible adversities, including some of
the domains not considered in the ACE Study.
maining 1496 of the completed interviews. Sample weights were
calculated to adjust for differential probability of selection associated with (1) study design, (2) demographic variations in
nonresponse, and (3) variations in within-household eligibility. For this study, we analyzed a subsample of the entire sample
of 4549 respondents. This subsample consisted of 2030 youth
who were aged 10 to 17 years at the time of the interview and
for whom complete data were available on the variables of interest. Analyses in this study are weighted by the sample weights.
PROCEDURE
A short interview was conducted with an adult caregiver (usually
a parent) in each household to obtain family demographic information. One child was randomly selected from all eligible children living in a household by choosing the child with the most
recent birthday. If the selected child was aged 10 to 17 years, the
main telephone interview was conducted with the child. If the child
was younger than 10 years, the interview was completed with the
caregiver. However, the current analysis is based only on the 2030
youth aged 10 to 17 years who provided self-report information.
Respondents were paid $20 for their participation. The interviews,
averaging 45 minutes in both waves, were conducted in either English or Spanish. All procedures were approved by the institutional
review board at the University of New Hampshire.
RESPONSE RATES
AND NONRESPONSE ANALYSES
The cooperation rate for the random digit dialing crosssection portion of the survey was 71%, and the response rate
was 54%. The cooperation and response rates associated with
the smaller oversample were somewhat lower at 63% and 43%,
respectively. These are good rates by current survey research
standards.26-30 Although the potential for response bias remains an important consideration, several recent studies and
our own analysis25 have shown no meaningful association between response rates and response bias.31-34
MEASUREMENT
Victimization and Adversity
METHODS
PARTICIPANTS
These analyses use data from the National Survey of Children’s Exposure to Violence (NatSCEV),25 a representative
sample of US children and adolescents. The NatSCEV was designed to obtain incidence and prevalence estimates for a wide
range of childhood victimizations and other adversities. The
survey was conducted between January 2008 and May 2008 with
a nationally representative sample of 4549 children aged 0 to
17 years living in the contiguous United States. Interviews with
parents and youth were conducted over the telephone by the
employees of an experienced survey research firm.
The foundation of the design was a nationwide sampling
frame of residential telephone numbers from which a sample
of telephone households was drawn by random digit dialing.
This nationally representative cross section yielded 3053 of the
4549 completed interviews. To ensure that the study included
a sizable proportion of racial/ethnic minorities and lowincome respondents for more accurate subgroup analyses, there
was also an oversampling of US telephone exchanges that had
a population of 70% or more of African American, Hispanic,
or low-income households. This oversample yielded the re-
This survey used an enhanced version of the Juvenile Victimization Questionnaire, an inventory of childhood victimization.35-37 The Juvenile Victimization Questionnaire obtains reports on 48 forms of youth victimization covering 5 general areas
of interest: conventional crime, maltreatment, victimization by
peer and siblings, sexual victimization, and witnessing and exposure to violence.38 The survey also contains questions about
adverse life events in the parent interview section and in a separate section on adversity.
For the present study, which was not originally designed
to test the ACE Study model, we selected victimization and adversity items in 2 steps. First, we used screener items and their
associated follow-up questions to construct victimization types
that most closely matched the abuse and neglect items in the
original ACE Study, and we chose family background and adversity items to match the household dysfunction items of the
original ACE Study. Using these items, we constructed a replication of the original ACE Study. In the second step, we selected additional types of victimization and adversity items not
included in the original ACE Study but that are known to be
important correlates of health and well-being outcomes. The
measures selected in these 2 steps are described in the next section of this article. Important differences from the ACE Study
items are noted in eTable 1 (http://www.jamapeds.com).
JAMA PEDIATR/ VOL 167 (NO. 1), JAN 2013
71
WWW.JAMAPEDS.COM
©2013 American Medical Association. All rights reserved.
Downloaded From: http://jamanetwork.com/ by George Morris on 04/20/2016
Measures Used to Replicate
Original ACE Study Items
The following measures were coded 0 for no and 1 for yes so
that they could be summed to create the replicated ACE Study
items. All are lifetime measures.
v Emotional abuse: One item asked respondents, “At any
time in your life, did you get scared or feel really bad because
grown-ups in your life called you names, said mean things to
you, or said they didn’t want you?”
v Physical abuse: Several screeners assessed the child’s experience of physical assault. Children who answered yes to any
of these assault screeners were coded as having experienced
physical abuse if the incident was perpetrated by parent, an adult
relative, or another adult caregiver.
v Sexual abuse: Four screeners asked about the child’s experience of sexual assault or attempted rape by a known adult,
an adult stranger, or a peer or sibling.
v Emotional neglect: Four questions about family social support were used to construct an indicator of emotional neglect.
These items are shown in eTable 1. Total scores ranged from 4
to 16. Children whose family support score was 10 or lower
were coded as having experienced emotional neglect.
v Physical neglect: A single item asked whether the child had
ever experienced a time when adults in his or her life “didn’t take
care of them the way they should,” including not providing enough
food, not taking them to the doctor when they were sick, or not
making sure they had a safe place to stay. Children who answered yes were coded as having experienced physical neglect.
v Mother treated violently: Twelve screeners asked children whether they had witnessed specific kinds of violence and
abuse. Children who answered yes to any of these questions
and who reported that their mother was the victim were coded
1 on this item.
v Household substance abuse: A single item assessed whether
the child had a family member who “drank or used drugs so
often that it caused problems.”
v Household mental illness: Children who had a parent or
sibling with depression, bipolar disorder, anxiety, or “other psychiatric disorder” (information obtained from the parent interview) or children who had “someone close” attempt suicide were coded 1 on household mental illness.
v Parental separation or divorce: We coded any respondent
who was not currently living with 2 biological or adoptive parents as having experienced parental separation or divorce.
v Incarcerated household member: One adversity item asks
whether a parent or guardian had ever been sent to prison.
Additional Victimization and Adversity Items
Not Included in ACE Study
The measures listed herein, not included in the ACE Study, were
examined as additional correlates of children’s distress. A summary of these items is reported in eTable 2. Unless otherwise
specified, questions regarding these items were asked in the
child’s portion of the interview:
v Peer victimization (assault, physical intimidation, or emotional victimization by a nonsibling peer)
v Parents always arguing (respondents were asked whether
there was a time in their lives when their parents were always
arguing)
v Property victimization (experience of a robbery, theft, or
vandalism by a nonsibling perpetrator)
v Someone close to the child had a bad accident or illness
v Exposure to community violence (6 screeners asked
whether the child had been exposed to certain types of crime
and violence, including witnessing an assault, experiencing a
household theft, having someone close murdered, witnessing
a murder, experiencing a riot, or being in a war zone)
v No good friends (child had no “really good friends at
school” at the time of the interview)
v Below-average grades (parent reported that the child had
“below-average” grades in school)
v Someone close to the child died because of an accident
or illness
v Parent lost job (children reported that there was a time
when their “mother, father, or guardian lost a job or couldn’t
find work”)
v Parent deployed to war zone (parent had to leave the country to fight in a war and was gone for several months or longer)
v Disaster (child had experienced a “very bad fire, flood, tornado, hurricane, earthquake, or other disaster”)
v Removed from family (child was “sent or taken away from
his or her family for any reason”)
v Very overweight (parent reported that the child was “quite
a bit overweight” compared with other boys/girls his or her age)
v Physical disability (parent reported that the child had been
diagnosed with a “physical health or medical problem that affects the kinds of activities that he or she can do”)
v Ever involved in a bad accident
v Neighborhood violence is a “big problem” (asked in the
parent interview)
v Homelessness (a time when the child’s family “had to live
on a street or in a shelter because they had no other place to stay”)
v Repeated a grade
v Less masculine or feminine than other boys or girls his
or her age (asked in the parent interview)
Distress Symptoms
Distress symptoms were measured using shortened versions of
the anger, depression, anxiety, dissociation, and posttraumatic stress scales of the Trauma Symptoms Checklist for Children (TSCC).39 Respondents were asked how often they had
experienced each symptom within the past month. Response
options were on a 4-point scale from 1 (not at all) to 4 (very
often), and responses from the items of all 5 scales were summed
to create a total distress score consisting of 28 items. The Cronbach ? value for total distress score in this study was 0.93.
Demographics
Demographic information was obtained in the initial parent interview, including the child’s sex, age (in years), race/
ethnicity (coded into 4 groups: white non-Hispanic, black nonHispanic, other non-Hispanic, and Hispanic any race),
socioeconomic status (SES), and place size of the child’s town
or city of residence. Socioeconomic status is a continuous composite score based on the sum of the standardized household
income and standardized parental educational level (for the parent with the highest educational level) scores, which was then
restandardized. For our revised version of the ACE scale, we
created a dummy indicator for low SES that flags children whose
continuous SES value fell in the bottom, roughly 20%.
RESULTS
The ACE scale constructed with variables from NatSCEV
that mimic the original items is associated with distress
levels among youth aged 10 to 17 years, as measured by
the Trauma Symptom Checklist for Children. Model 1
in Table 1 reports the regression of distress scores on
JAMA PEDIATR/ VOL 167 (NO. 1), JAN 2013
72
WWW.JAMAPEDS.COM
©2013 American Medical Association. All rights reserved.
Downloaded From: http://jamanetwork.com/ by George Morris on 04/20/2016
Table 1. Regression of Wave 1 Trauma Scores
on Lifetime Victimization and Adversity
Table 2. Items in Original and Revised ACE Scales
ACE Scale Adversities (Lifetime)
Regression
Coefficient, ? a
Characteristic (n = 2030)
Demographics, time 1 b
Age, mean, y
Male sex
Black, non-Hispanic
Other, non-Hispanic
Hispanic, any race
ACE scale items
Physical abuse
Emotional abuse
Emotional neglect
Physical neglect
Household mental illness
Household substance abuse
Sexual abuse
Mother treated violently
Incarcerated household member
Parental separation or divorce
Additional victimization and adversity items
Peer victimization (nonsibling)
Parents always arguing
Property victimization (nonsibling)
Someone close had a bad accident or
illness
Exposure to community violence
No good friends
Socioeconomic status
Below-average grades
Someone close died from
illness/accident
Parent lost job
Parent deployed to war zone
Disaster
Removed from family
Very overweight
Physical disability
Involved in a bad accident
Neighborhood violence is “big problem”
Family homeless
Repeated a grade
Less masculine or feminine than peers
Adjusted R 2
%
Model
1
Model
2
13.5
51.2
15.1
5.7
17.8
?0.01
?0.03
0.01
?0.05 d
?0.02
?0.03
?0.08 c
0.03
?0.05 e
?0.03
14.9
17.7
7.7
4.0
27.9
16.8
6.6
13.1
11.1
41.2
0.16 c 0.13 c
0.16 c 0.08 c
0.12 c 0.12 c
0.09 c 0.07 c
0.08 c 0.04 e
0.08 c 0.01
0.08 c 0.05 d
0.05 e ?0.02
0.02 ?0.01
?0.01 ?0.05 e
47.6
22.0
41.0
64.4
0.17 c
0.15 c
0.11 c
0.10 c
63.4
1.8
0.04
6.1
49.3
0.09 c
0.07 c
?0.06 d
0.04 e
0.05 e
19.5
9.9
10.9
4.8
3.0
6.9
13.8
4.3
3.2
13.2
8.7
0.04 e
0.04
0.03
0.03
0.02
?0.01
?0.02
?0.02
?0.02
?0.03
?0.03
0.36
0.24
Abbreviation: ACE, Adverse Childhood Experiences.
a Change in adjusted R 2 was significant at P ? .001.
b Reference category for race/ethnicity is white, non-Hispanic (61.4 % of
sample).
c Coefficient is significant at P ? .001.
d Coefficient is significant at P ? .01.
e Coefficient is significant at P ? .05.
the items from the replicated ACE scale. The cumulative items were strongly associated with distress, and there
was a clear dose-response relationship between the adversities and distress, as has been demonstrated in previous research.1
However, the original ACE scale items did not each
make an independent contribution to distress as illustrated in model 1 of Table 1. Two items, parental separation or divorce and incarceration of a household member, were not significant in the regression model of the
whole scale. In addition, when other childhood adversi-
Original
Emotional abuse
Physical abuse
Sexual abuse
Physical neglect
Emotional neglect
Mother treated violently
Household substance abuse
Household mental illness
Incarcerated household member
Parental separation or divorce
Emotional abuse
Physical abuse
Sexual abuse
Physical neglect
Emotional neglect
Household mental illness
Property victimization
(nonsibling)
Peer victimization (nonsibling)
Exposure to community violence
Socioeconomic status
Someone close had a bad
accident or illness
Below-average grades
Parents always arguing
No good friends (at time of
interview)
Abbreviation: ACE, Adverse Childhood Experiences.
ties (not considered in the ACE studies) were added to the
model (model 2 of Table 1), several ACE scale items
dropped below significance. Moreover, several of the added
childhood adversities showed strong associations with distress. These included peer victimization, property victimization, parents always arguing, having no good friends,
having someone close with a bad illness or accident, SES,
and exposure to community violence.
A revised ACE scale was then constructed, removing
the original items that were no longer significant in the
extended model. Significant new items were added to the
scale, including parents always arguing, having no good
friends, having someone close with a bad illness or accident, peer victimization, property victimization, and exposure to community violence. The old and new scales
are contrasted in Table 2. Regression with the new scale
determined R2 = 0.34 vs R2 = 0.21 for the original version of the scale.
COMMENT
In this study, it was possible to improve the value of the
original ACE scale considerably by adding some childhood adversities not included in the original scale and
excluding others that were in the scale. The value of adding several items not considered in the ACE studies is
consistent with several publications showing their harmful effect on child development. In fact, there are likely
even more domains of childhood adversity that might be
measured and added that could further improve its predictive ability, for example, low IQ,40 parental death, and
food scarcity. The present study illustrates that the original ACE scale could likely be improved even more with
additional developmental research.
However, this analysis also confirms that some of the
key ACE scale items, particularly the child maltreatment exposures, remain very important and make discrete independent contributions, even when many other
adversities are considered. Moreover, several of the new
JAMA PEDIATR/ VOL 167 (NO. 1), JAN 2013
73
WWW.JAMAPEDS.COM
©2013 American Medical Association. All rights reserved.
Downloaded From: http://jamanetwork.com/ by George Morris on 04/20/2016
Revised
adversities identified in this study are additional forms
of interpersonal victimization—property crime, peer victimization, and exposure to community violence—
which reinforce findings from other studies41,42 highlighting the cumulative harm of different forms of
childhood victimization.
There are several limitations of the current study that
bear emphasis. First, this study did not operationalize the
adverse childhood events in the same way that the original ACE instrument did. Second, the dependent variable, the TSCC, used in this exercise was not an outcome used in the original ACE Study. The TSCC may be
better associated with the impact of some childhood
events, such as violence exposure, than others and may
not necessarily be reflective of what would best predict
long-term health effects. In fact, some childhood adversities may affect later health not through psychological
processes, such as distress symptoms, but through other
mechanisms, for example, failure to receive proper early
health care. Moreover, unlike the ACE Study, the outcome measure was short term and the causal sequence
between adversities and outcome cannot be assumed. All
the variables in this study come from self-report and, in
most cases, from children, which may be inaccurate and
introduce method associations.
Before additional work on the ACE scale is undertaken, some important issues are worth discussing, even
beyond the findings of the current study. One issue concerns what the goal or best use of this or related scales
should be. One possible use for this kind of scale is as a
risk assessment tool with older adolescents or adults to
help health care providers better understand who is most
likely to require services and treatment for health problems. However, the goal for which the scale has been most
widely used to date is to advocate for and influence prevention policies by highlighting crucial developmental
factors that prevention programs should target to improve general health and reduce medical costs and social service expenditures.22,43,44
In many ways the first goal, risk assessment, is a much
easier one to accomplish than the second, selection of prevention targets. To successfully satisfy the first goal, research has to find strong associations between risk indicators and later outcomes. The ACE scale seems clearly
successful at this. For the second goal, however, a good risk
indicator is not sufficient. The indicator has to be a proven
causal contributor, which modified would make a difference. Much of the discussion about the ACE scale assumes that its items are causal contributors to the numerous negative adult outcomes, but this may not be the case.
Without detailed longitudinal studies and the measurement of many additional variables, it may be very difficult to tease out whether, for example, it is household substance abuse that affects later outcomes or some
unmeasured underlying parental emotional problem or lack
of self-control. Moreover, a very important, but difficult
to test, alternative explanation for many of the ACE Study
findings is that inherited genes for health problems or some
temperamental qualities create a spurious connection between abuse and neglect by parents or other family context variables and mental and physical health conditions
in their offspring. If this were to be the case, it is possible,
although not likely, that even preventing child abuse would
make modest differences on health outcomes.
There are other problems with using an ACE scale even
as a long-term risk assessment tool. One is that risk assessment has to factor in social changes regarding the frequency, norms, and impact of different experiences. For
older respondents who answered the original ACE Study
questionnaire, parental divorce may have been an unusual and stigmatizing event and sexual abuse a hidden
experience that one never talked or heard anything about.
Among a younger cohort, more cultural awareness and
the increased availability of support, including professional intervention, may mean that the experience of
sexual abuse or parental divorce might have different consequences. This may be why parental divorce was not a
significant predictor in the current study.
Another problem is the possibility of reverse causation in which bad later life outcomes induce reports of
more negative early childhood experiences. There is some
evidence that people recall more negative historical adversity when they have poor adult outcomes, mental
health, and physical problems.45 To the degree that this
is true, variables identified in later life, such as in the ACE
Study, will not prove as predictive of ultimate health outcomes when assessed in earlier life stages.
An additional philosophical problem worth considering in discussions about the implications of ACE-type
research is whether advocates should use a list of childhood features that are associated with long-term health
effects as the primary criterion of what childhood adversities to prioritize for prevention. For example, if sexual
abuse were demonstrated to be minimally associated with
long-term health effects, would that disqualify it as a priority for primary prevention? No. Many childhood adversities are candidates for prevention not because they
create long-term health risks but because they violate the
rights of children or cause pain and suffering at the moment. Their contributions to long-term health can be additional evidence to consider but may not be primary.
Such adversities illustrate the tension between a utilitarian and human rights perspective in child welfare policy.
CONCLUSIONS
This research suggests that the goal of identifying childhood adversities that are precursors to long-term health
and behavioral outcomes may be improved by considering a wider range of adversities measured in a more contemporaneous way. Such an approach might be well advanced by using longitudinal studies that have been
monitoring children into adulthood.12
However, more discussion is needed about the goals
and usefulness of such efforts. Although additional efforts to refine an adverse childhood experience checklist that predicts later health outcomes has scientific merit,
an argument can be made that enough is known about
certain harmful childhood experiences22 that more testing of parts of this model should be carried out through
experiment rather than correlation. There is enough consensus that exposure to violence, sexual abuse, and emotional mistreatment are harmful and likely have long-
JAMA PEDIATR/ VOL 167 (NO. 1), JAN 2013
74
WWW.JAMAPEDS.COM
©2013 American Medical Association. All rights reserved.
Downloaded From: http://jamanetwork.com/ by George Morris on 04/20/2016
term health effects; therefore, the next generation of
studies should probably focus on preventing and remediating these exposures and following up to determine
whether health outcomes improve.
Accepted for Publication: June 7, 2012.
Published Online: November 26, 2012. doi:10.1001
/jamapediatrics.2013.420
Correspondence: David Finkelhor, PhD, Crimes Against
Children Research Center, University of New Hampshire, 126 Horton Social Science Center, 20 Academic
Way, Durham, NH 03824 ([email protected]).
Author Contributions: Study concept and design: Finkelhor, Turner, and Hamby. Analysis and interpretation of
data: Finkelhor, Shattuck, Turner, and Hamby. Drafting
of the manuscript: Finkelhor and Shattuck. Critical revision of the manuscript for important intellectual content:
Finkelhor, Turner, and Hamby. Statistical analysis:
Shattuck. Obtained funding: Finkelhor and Turner. Administrative, technical, and material support: Finkelhor and
Turner. Study supervision: Finkelhor.
Conflict of Interest Disclosures: None reported.
Online-Only Material: The eTables are available at http:
//www.jamapeds.com.
REFERENCES
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
1. Felitti VJ, Anda RF, Nordenberg D, et al. Relationship of childhood abuse and
household dysfunction to many of the leading causes of death in adults: the Adverse Childhood Experiences (ACE) Study. Am J Prev Med. 1998;14(4):245258.
2. Anda RF, Croft JB, Felitti VJ, et al. Adverse childhood experiences and smoking
during adolescence and adulthood. JAMA. 1999;282(17):1652-1658.
3. Dietz PM, Spitz AM, Anda RF, et al. Unintended pregnancy among adult women
exposed to abuse or household dysfunction during their childhood. JAMA. 1999;
282(14):1359-1364.
4. Anda RF, Felitti VJ, Chapman DP, et al. Abused boys, battered mothers, and male
involvement in teen pregnancy. Pediatrics. 2001;107(2):E19. doi:10.1542/peds
.107.2.e19.
5. Anda RF, Whitfield CL, Felitti VJ, et al. Adverse childhood experiences, alcoholic
parents, and later risk of alcoholism and depression. Psychiatr Serv. 2002;
53(8):1001-1009.
6. Dong M, Dube SR, Felitti VJ, Giles WH, Anda RF. Adverse childhood experiences and self-reported liver disease: new insights into the causal pathway. Arch
Intern Med. 2003;163(16):1949-1956.
7. Dube SR, Anda RF, Felitti VJ, Croft JB, Edwards VJ, Giles WH. Growing up with
parental alcohol abuse: exposure to childhood abuse, neglect, and household
dysfunction. Child Abuse Negl. 2001;25(12):1627-1640.
8. Dube SR, Felitti VJ, Dong M, Chapman DP, Giles WH, Anda RF. Childhood abuse,
neglect, and household dysfunction and the risk of illicit drug use: the Adverse
Childhood Experiences Study. Pediatrics. 2003;111(3):564-572.
9. Hillis SD, Anda RF, Felitti VJ, Nordenberg D, Marchbanks PA. Adverse childhood experiences and sexually transmitted diseases in men and women: a retrospective study. Pediatrics. 2000;106(1):E11. http://pediatrics.aappublications
.org/content/106/1/e11.long. Accessed February 3, 2012.
10. Dube SR, Anda RF, Felitti VJ, Chapman DP, Williamson DF, Giles WH. Childhood abuse, household dysfunction, and the risk of attempted suicide.