Short Answer Questions:Lecture 1#1. In a few sentences, define “Precision Medicine” in your own words. Also, briefly explain what you believe are the benefits of Precision Medicine and why you think such an approach would not have been possible earlier. #2. In 3-4 sentences per application, describe two diagnostic applications of Precision Medicine (disease or phenotypic indication, whether DTC or clinical, diagnostic technology platform, example of test result, and how results are utilized by the clinician or consumer). Draw from workshop material and PowerPoints as needed.Lecture 2#1. In a few sentences, describe in your own words the difference between oncogenes and tumor suppressor genes and the roles that they place in cancer development.#2. In one paragraph (5-6 sentences), based on your understanding of cancer genetics, cancer genomics, and cancer genomic heterogeneity (both between and within patients), describe some of the fundamental elements of human cancer genome landscapes and the importance of genomic sequencing for individual patients in the context of those elements.Lecture 3#1. In a few sentences, define “diagnostic Odyssey” in your own words. Also, briefly describe how the next-generation sequencing (NGS) technology can help in shortening the “diagnostic odyssey”.#2. Briefly describe “X-inactivation.” What is it and why does it happen? What is its role in genetic disorders?
MOLECULAR PATHOLOGY OF
CANCER: SCREENING, PROGNOSIS,
DIAGNOSIS, AND TREATMENT
BMMAG/BMMSG 841: Precision Medicine
Week 2, Lecture 2, 2024
William Hendricks, Ph.D.
Assistant Professor, Integrated Cancer Genomics Division, TGen
Chief Scientific Officer, Vidium Animal Health
What can you expect to learn from this lecture?
• General features of current cancer incidence and mortality rates (cancer
epidemiology)
• The genetic and biologic basis of cancer
• Differentiate familial versus sporadic cancers, key features and examples of
each
• Describe fundamental aspects of cancer genome landscapes
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Cancer epidemiology
The genetic and biologic basis of cancer
Familial versus sporadic cancers
Cancer genomics and cancer genome landscapes
Epidemiology: The study of the distribution and determinants of
health-related states or events in specified populations, and the
application of this study to the control of health problems
(www.cdc.gov).
